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J Clin Pathol 2002;55:648-655 doi:10.1136/jcp.55.9.648
  • Review

Cell kinetics and cell cycle regulation in lymphomas

  1. L Leoncini,
  2. S Lazzi,
  3. C Bellan,
  4. P Tosi
  1. Institute of Pathological Anatomy and Histology, University of Siena, 53100 Siena, Italy
  1. Correspondence to:
 Professor L Leoncini, Institute of Pathological Anatomy and Histology, University of Siena, Strada delle Scotte 6, 53100 Siena, Italy;
 leoncinil{at}unisi.it
  • Accepted 22 August 2001

Abstract

The proliferative indices of non-Hodgkin's lymphomas are useful prognostic indicators and provide information independent of other histological and clinical variables. However, proliferative indices alone do not suffice to characterise cell growth. A high cell production rate may be compensated, almost or fully, by a high cell deletion rate. A re-evaluation of parameters of cell kinetics in view of our increasing knowledge of the molecular pathways of cell cycle control may provide more prognostic information for the management of patients with malignant lymphomas.

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