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J Clin Pathol 55:121-126
  • Original article

Correlation between cathepsin D expression and p53 protein nuclear accumulation in oesophageal squamous cell carcinoma

Table 4

Univariate and multivariate analysis of prognostic factors of patients with oesophageal squamous cell carcinoma

Variable HR 95% CI p Value
HR, hazard ratio; CI, confidence interval.
Univariate analysis
    Invasion to adventitia
        Present v absent 4.184 2.451 to 7.143 <0.001
    Lymph node metastasis
        Present v absent 4.926 2.841 to 8.547 <0.001
    Distant metastasis
        Present v absent 8.403 3.745 to 18.868 <0.001
    Cathepsin D expression
        Positive v negative 1.583 1.002 to 2.502 0.049
    p53 expression
        Positive v negative 1.502 0.67 to 1.651 0.827
Multivariate analysis
    Invasion to adventitia
        Present v absent 2.762 1.575 to 4.854 <0.001
    Lymph node metastasis
        Present v absent 3.546 1.992 to 6.289 <0.001
    Distant metastasis
        Present v absent 4.525 2.004 to 10.204 <0.001
    Cathepsin D expression
        Positive v negative 1.325 0.832 to 2.111 0.236

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