Table 4
Summary of studies investigating the role of human papillomavirus (HPV) in large cell neuroendocrine carcinoma (LCNEC) of the cervix
| Reference | HPV type | No. of cases positive |
|---|---|---|
| *Also rare positive signals with HPV-31/33 probe in some cases; †exact number of HPV positive LCNECs not specifically stated; ‡HPV-16 detected by NISH and/or PCR in seven tumours and HPV-18 detected by NISH and/or PCR in two tumours. | ||
| NISH, non-isotopic in situ hybridisation; PCR, polymerase chain reaction. | ||
| Mannion et al (1998)3 | 16/18* | ?/5† |
| Wistuba et al (1999)4 | 18 | 1/2 |
| Yun et al, (1999)5 | 16 | 1/1 |
| Present series (2001) | 16, 18‡ | 9/12‡ |
