Thrombin switches on RANTES synthesis in RA
Researchers have shown for the first time that development of rheumatoid arthritis (RA) entails stimulation of synthesis of a chemokine by thrombin. They further suggest that the expression of the RANTES chemokine’s mRNA occurs by a protease activated receptor-1 (PAR-1) pathway.
PAR-1 and PAR-3 were expressed in isolated …








