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J Clin Pathol 55:900-905 doi:10.1136/jcp.55.12.900
  • Original article

Histological grading of papillary urothelial carcinoma of the bladder: prognostic value of the 1998 WHO/ISUP classification system and comparison with conventional grading systems

Table 4

1998 WHO/ISUP grading system. Characteristics and outcome of different grades: grading of recurrent tumours by modified 1973 WHO6,8 and staging by TNM16

First recurrence First progression
Grade of primary tumour (1998 WHO/ISUP)10 N Mean time to recurrence (months) Grade N Stage N Stage N
ISUP, International Society of Urologic Pathology; WHO, World Health Organisation.
Papilloma 18 61 1 1 Ta 3 Tis 0
2a 1 T1 0 T1 0
2b 1 T2 0 T2 0
3 0 Tis 0
Low malignant potential 116 30 1 5 Ta 28 Tis 0
2a 22 T1 1 T1 2
2b 1 T2 1 T2 1
3 2 Tis 0
Low grade carcinoma 141 20 1 8 Ta 39 Tis 1
2a 26 T1 2 T1 4
2b 8 T2 1
3 1 Tis 1
High grade carcinoma 45 20 1 1 Ta 16 Tis 0
2a 4 T1 1 T1 1
2b 11 T2 1 T2 1
3 2 Tis 0

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