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J Clin Pathol 55:885-891 doi:10.1136/jcp.55.12.885
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HPV infections and lung cancer

Table 1

Detection of HPV DNA in bronchial papillomas and carcinomas

HPV type detected
Type of lesion Technique No. of cases 6 6/11 11 16 16/18 18 Other Total (%) HPV+ First author (year)
*Three additional cases with HPV-31/33/35; †two additional cases with HPV-31/33/35; ‡HPV-31 and HPV-33; §ISH for HPV-6/11, HPV-16/18, and HPV-31/33/51; ¶oncogenic types in HCII assay; **HPV-6/16; ††HPV-11/16; ‡‡triple infections.
AdC, adenocarcinoma; AnSCC, anaplastic carcinoma; ASC, adenosquamous carcinoma; ASSC, alveolar carcinoma; DB, dot blot hybridisation; EM, electron microscopy; FISH, filter in situ hybridisation; HCII, hybrid capture II; ISH, in situ hybridisation; LCC, large cell carcinoma; ND, not defined; PCR, polymerase chain reaction; SB, Southern blot hybridisation; SCC, small cell carcinoma; SCP, squamous cell papilloma; SQC, squamous cell carcinoma; SQM, squamous cell metaplasia.
SQC SB 9 0 Stremlau (1985)34
LCC SB 7 0
ASC SB 2 0
ASC SB 5 1 20
SQC SB 1 1 100 Byrne (1987)35
SQC ISH 99 5 5 Syrjänen(1987)36
SCP EM 1 100 Trillo (1988)33
SQC ISH 131 2 7 7 Syrjänen (1989)37
SCP ISH 1 1 100 Kerley (1989)38
SCP ISH 15 1 7 Carey (1990)39
SQM ISH 10 1 10 Bejui-Thivol (1990)40
SQC ISH 33 1 1 1 3 18
SQC ISH 1 1 100 Bejui-Thivol (1990)41
SQC FISH 5 2 40 Kulski (1990)42
SCP ISH 6 6 100 Popper (1992)43
SQC ISH 5 5*† 100
SQC ISH 1 1 100 DiLorenzo (1992)44
SQM ISH 17 1 1 12 Yousem (1992)45
SQC ISH 20 1 2 15
ASC ISH 12 0
ASSC ISH 16 0
SQC ISH 4 0
LCC ISH 6 1 17
SCP ISH 2 2 100
SQC PCR, SB 29 3 0 10 Ogura (1993)46
SCP ISH 1 1 100 Katial (1994)47
SQC PCR, ISH 49 1 5 1 14.2 Liu (1994)48
SCP PCR 20 3 6 2 55 Popper (1994)49
SQC PCR 11 1 9
SQC, AdC PCR 85 0 Shamanin (1994)50
LSSC PCR 7 0 Szabo (1994)51
SQC PCR 40 0
SQC PCR, ISH 49 4 2 2 16.3 Xing (1994)52
SQC PCR 66 3 1 2 9 Al-Ghamdi (1995)53
SQC DB, SB, PCR 10 1 10 Kinoshita (1995)54
AdC DB, SB, PCR 26 2 9
SQC DB, PCR 50 10 1 5 32 Li (1995)55
ASSC ISH, PCR 22 2 3 1 1 10‡ 36 Nuorva (1995)56
SQC DB. PCR 27 7 1 5 48 Qingquan (1995)57
AdC DB, PCR 16 2 0 0 12
SQC DB, PCR 2 1 0 0 50
ASC DB, PCR 5 0
SCC PCR 8 1 12.5 Sagawa (1995)58
SQC PCR 18 1 1 11 Thomas (1995)59
SQC PCR 34 12 Zhang (1995)60
SQC PCR 9 9 100 Da (1996)61
SQC PCR 16 8 50
AdC PCR 12 5 42
AdC PCR 4 1 1 50 Thomas (1996)62
LCC PCR 2 0
SQC PCR 7 2 28
SQC PCR, ISH 73 11 26 4 56 Hirayasu (1996)63
AdC PCR 41 2 6 20 Noutsou (1996)64
SQC PCR 41 2 2 10
LCC PCR 10 3 2‡ 20
SQC PCR 7 0
SQC ISH, PCR 28 5 4 6 4 1‡ 67 Soini (1996)65
AdC ISH, PCR 12 1 2 2 3 5‡ 75
SQC ISH, PCR 3 0
SQC PCR ND ND ND ND 79 Nakazato (1997)66
SQC ISH, PCR 32 0 Welt (1997)67
SQC ISH, PCR 6 0
SQC ISH, PCR 34 2 6 Bohlmeyer (1998)68
SCP ISH, PCR 14 5§ 36 Flieder (1998)30
SCC PCR, SB 52 6 11 ND 69 Papadopoulou (1998)69
ASC ISH, PCR 23 18 ND 78 Tsuhako (1998)70
SCC PCR 35 0 Wistuba (1998)71
SQC PCR, ISH 31 0 Gorgoulis (1999)72
AdC PCR, ISH 32 0
LCC PCR, ISH 5 0
SQC PCR 1 1 100 Hennig (1999)73
SQC ISH, PCR 75 12 1†† 18 (5)** 1 49 Hennig (1999)74
AdC PCR, EM 285 1 ND 0.4 Hiroshima (1999)75
SCP PCR 1 1 100 Kawaguchi (1999)76
SQC HCII 185 5¶ 2.7 Clavel (2000)77
SCP ISH, PCR 1 1 1 100 Harada (2000)78
SQC ISH, PCR 44 ND 57 Iwamasa (2000)79
SQC ISH, PCR 157 9 16 22 25 5‡‡ 49 Miyagi (2000)80
SQC ISH, PCR 141 77 55 Cheng (2001)81
SQC ISH 26 1 2 11.5 Kaya (2001)82
SQC ISH 22 1 4.5 Miasko (2001)83
AdC ISH 13 1 7.6
LCC ISH 5 1 20
SQC ISH, PCR 59 29ND 49 Miyagi (2001)84
AdC ISH, PCR 62 12ND 19.4

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