Table 1
Patient characteristics
| Case | Age (sex) | Duration of ITP | ITP treatment | Antibody deficiency and duration | Alkaline phosphatase (normal range, 25–100 IU/l) | Splenic histology | Anti-D dose |
|---|---|---|---|---|---|---|---|
| CVID, common variable immunodeficiency; ITP, immunec thrombocytopenia; IVIG, intravenous immunoglobulin; NA, not available. | |||||||
| 1 | 62 years (female) | 1 year | IVIG, steroids | CVID, 2 years | 170–270 IU/l | NA | 50 μg/kg |
| 2 | 21 years (female) | 15 years | IVIG, steroids, azathioprine, cyclosporin | CVID, 7 years | 150–200 IU/l | Lymphocytosis of red pulp | 50 μg/kg |
| Splenectomy | Focal aggregates of foamy macrophages | ||||||
| 3 | 21 years (female) | 1 year | IVIG, steroids | CVID, 8 years | 68–78 IU/l | NA | 100 μg/kg |
| 4 | 20 years (female) | 5 years | IVIG, steroids, dapsone, cyclosporin, azathioprine, vincristine | IgG2, 4, and IgA deficiency, raised IgM, 15 years | 54–67 IU/l | Follicular hyperplasia | 150 μg/kg |
| Splenectomy | Prominent germinal centres | ||||||
