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J Clin Pathol 54:689-692

Loss of heterozygosity at cylindromatosis gene locus, CYLD, in sporadic skin adnexal tumours

Table 1

Loss of heterozygosity (LOH) in skin adnexal tumours

Type (no.) 16p (D16s407) 16q (D16s308) 16q (D16s304) Overall LOH at 16q
The data are presented as number of cases exhibiting LOH/number informative for that marker (%).
*One case showed LOH at both 16q markers.
NI, not informative; no, number of cases studied.
Cylindroma (4) 0/4 (0%) 2/4 (50%)* 2/3 (67%)* 75%
Trichoepithelioma (2) 0/1 (0%) NI 1/2 (50%) 50%
Apocrine hydrocystoma (4) 0/3 (0%) 0/3 (0%) 1/3 (33%) 33%
Eccrine spiradenoma (7) 0/5 (0%) 0/5 (0%) 1/5 (20%) 20%
Sebaceous adenoma (4) 0/2 (0%) 1/3 (33%) 1/3 (33%) 66%
Syringoma (7) 1/5 (20%) 0/3 (0%) 1/5 (20%) 20%
Eccrine hydrocystoma (5) 1/4 (25%) 0/5 (0%) 0/4 (0%) 0%
Trichofolliculoma (8) 0/6 (0%) 0/8 (0%) 0/5 (0%) 0%
Eccrine poroma (8) 0/6 (0%) 0/7 (0%) 0/7 (0%) 0%
Trichilemmoma (4) 0/3 (0%) 0/3 (0%) 0/1 (0%) 0%
Eccrine carcinoma (1) NI 0/1 (0%) 0/1 (0%) 0%
Desmoplastic trichoepithelioma (1) 0/1 (0%) NI 0/1 (0%) 0%
Basal cell carcinoma (9) 0/5 (0%) 1/8 (13%) 0/5 (0%) 13%
Squamous cell carcinoma (5) 0/3 (0%) 0/4 (0%) 0/3 (0%) 0%

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