Reduced expression of α-catenin, β-catenin, and γ-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer

Table 2

Distribution of staining of different catenins as related to clinicopathological factors

	α-Catenin					β-Catenin					γ-Catenin
	<10%	10–90%	≥90%	N	p Value	<10%	10–90%	≥90%	N	p Value	<10%	10–90%	≥90%	N	p Value
Numbers are percentages of cases identified in the three groups: <10%; 10–90%; ≥90%.
Histology
Squamous cell carcinoma	24	49	27	146		16	69	15	145		15	64	21	146
Adenocarcinoma	5	33	62	58	<0.0001	10	24	66	58	<0.0001	13	29	58	59	<0.0001
Anaplastic/large cell carcinoma	37	41	22	27		23	58	19	26		43	42	15	26
Histological grade
Grade I	20	20	60	15		6	44	50	16		6	38	56	16
Grade II	11	47	42	96	0.005	12	54	34	94	0.007	9	58	33	96	0.005
Grade III	25	48	27	88		18	60	22	87		21	53	26	85
Stage
Stage I	19	43	38	146		16	56	28	149		16	53	31	147
Stage II–IV	24	47	29	81	0.6	15	55	30	76	0.2	20	52	28	80	0.6
Tumour size
T1	18	39	43	61		14	49	37	63		18	49	33	63
T2–4	21	46	33	165	0.4	16	60	24	161	0.2	17	54	29	164	0.8
Lymph node status
NO	19	44	37	154		15	58	27	156		15	55	30	154
N1–3	24	44	32	72	0.6	16	53	31	68	0.7	22	48	30	73	0.4

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Reduced expression of α-catenin, β-catenin, and γ-catenin is associated with high cell proliferative activity and poor differentiation in non-small cell lung cancer

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