Table 3
The various morphological, morphometric, immunohistochemical, and molecular biological findings in AAH and adenocarcinoma
| Low grade AAH | High grade AAH | Adenocarcinoma (including BAC) | |
|---|---|---|---|
| AAH, atypical adenomatous hyperplasia; AgNOR, silver stained nucleolar organising region; BAC, bronchioloalveolar cell carcinoma; CEA, carcinoembryonic antigen; LOH, loss of heterozygosity. | |||
| Cellularity and atypia | + | ++ | +++ |
| Mean nuclear area | + | ++ | +++ |
| Nuclear DNA content | + | ++ | ++ |
| Aneuploidy | + | ++ | ++ |
| AgNOR count | + | ++ | +++ |
| CEA, p450, ApoA expression | + | ++ | ++ |
| p53 expression | + | ++ | +++ |
| K-ras mutation | −/+ | + | ++ |
| C-erb-B2 expression | + | ++ | |
| Loss of Rb and p16 | + | ||
| 3p, 7p, 17p/q LOH | + | ++ | |
| Blood group antigen expression | +++ | + | + |
| Cyclin D1 overexpression | +++ | ++ | + |
