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J Clin Pathol 54:219-223 doi:10.1136/jcp.54.3.219

Genetic diversity in the Helicobacter pylori cag pathogenicity island and effect on expression of anti-CagA serum antibody in UK patients with dyspepsia

Table 4

Features of Helicobacter pylori isolates and patients with sera giving negative or borderline results in the CagA ELISA assay

Strain Strain genotype Patient age (years) Clinical details
Strain genotype: cagA*, strain gave negative result with F1/B1 primer pair but was positive with the F008/R008 primer pair; ES+*, non-specific product amplified as well as predicted amplicon; ES−*, only non-specific product amplified.
DU, duodenal ulcer; ELISA, enzyme linked immunosorbent assay; GU, gastric ulcer.
CagA− ELISA
H292 cagA*/s1m1/ES+* 35 DU
H293 cagA*/s1m2/ES+ 55 Mild oesophagitis
H115 cagA*/s1m2/ES−* 56 GU
H377 cagA*/s1m2/ES−* 75 GU/DU
H298 cagA/s1m2/ES−* 67 DU
Borderline CagA ELISA
H6 cagA/s1m2/ES−* 37 DU
H339 cagA*/s1m1/ES−* 68 Gastric neoplasia

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