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J Clin Pathol 54:196-200 doi:10.1136/jcp.54.3.196

The usefulness of tyrosinase in the immunohistochemical assessment of melanocytic lesions: a comparison of the novel T311 antibody (anti-tyrosinase) with S-100, HMB45, and A103 (anti-melan-A)

Table 2

Summary of the intensity and distribution of melanoma cell staining for T311, A103, S-100, and HMB45 in malignant melanocytic lesions

T311 A103 S-100 HMB45
Staining: +, weak; ++, strong.
Nodular melanoma (5) ++ All cells (4) ++ All cells (2) ++ All cells (3) ++ All cells (1)
+ All cells (1) + All cells (1) + All cells (1) ++ Patchy (1)
++ Patchy (1) ++ Patchy (1) + Patchy (3)
+ Patchy (1)
Superficial spreading melanoma (9) ++ All cells (8) ++ All cells (8) ++ All cells (6) ++ All cells (5)
+ All cells (1) + Patchy (1) + All cells (2) + All cells (1)
+ Patchy (1) ++ Patchy (2)
+ Patchy (1)
Metastatic melanoma (5) ++ All cells (3) ++ All cells (3) ++ All cells (5) ++ All cells (4)
++ Patchy (1) ++ Patchy (1) ++ Patchy (1)
+ Patchy (1) + Patchy (1)
Desmoplastic melanoma (2) No staining (2) No staining (2) ++ All cells (2) No staining (2)
Lentigo maligna melanoma (2) ++ All cells (2) ++ All cells (2) ++ All cells (2) ++ All cells (2)
Acral lentiginous melanoma (2) ++ All cells (2) ++ All cells (2) ++ All cells (2) ++ All cells (1)
++ Patchy (1)

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