Primitive small round cell tumour of the adrenal gland presenting with fever of unknown origin and t(12;22)(q13;q12) cytogenetic finding
- 1Department of Pathology, University of Hong Kong, Queen Mary Hospital, Pokfulam Road, Hong Kong, China
- 2Department of Surgery, University of Hong Kong
- 3Department of Medicine, University of Hong Kong
- 4Department of Paediatrics, University of Hong Kong
- Dr Lam, Pathology Division, School of Medicine, James Cook University Douglas Campus, Townsville, Queensland, QLD 4811, Australia akylam{at}hotmail.com
- Accepted 21 May 2001
Abstract
This report describes a left adrenal tumour in a 16 year old Chinese girl who presented with fever of unknown origin. The histological and ultrastructural features of the adrenal tumour were those of a primitive small round cell tumour with neuroendocrine differentiation. Cytogenetic analysis of cultured tumour cells showed a reciprocal translocation t(12;22)(q13;q12). This is the first example of such a tumour being reported in the adrenal gland. The adrenal tumour was also the cause of the fever, which subsided after the removal of the tumour.
