Wegener's granulomatosis presenting as acute suppurative interstitial nephritis
- Department of Renal Medicine, Lister Hospital, Coreys Mill Lane, Stevenage, Hertfordshire SG1 4AB, UK
- Department of Molecular and Diagnostic Histopathology, Addenbrooke's Hospital, University of Cambridge, Hills Road, Cambridge CB2 2QQ, UK
- Dr Farrington Dr.FARRINGTON{at}lister.enherts-tr.nhs.uk
- Accepted 11 April 2001
Abstract
A 78 year old man presented with acute renal failure following a prolonged respiratory illness. A renal biopsy demonstrated severe suppurative interstitial nephritis with normal glomeruli. After nine weeks of antibiotics he remained anuric and a second biopsy demonstrated pauci-immune, necrotising glomerulonephritis. His subsequent clinical course was consistent with a diagnosis of Wegener's granulomatosis and antineutrophil cytoplasmic antibodies (ANCA) were detected. This is the first reported case of Wegener's granulomatosis presenting with an isolated tubulointerstitial lesion.
