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J Clin Pathol 54:766-770

Malignant mesothelioma: a comparison of biopsy and postmortem material by light microscopy and immunohistochemistry

Table 2

Comparison of immunohistochemical staining for biopsy and postmortem specimens

Specimen Subtype CAM5.2 VIM HBME-1 TM CAL CD44H WT-1 CEA Leu-M1 Ber-EP4 EMA p53
Specimen: B, biopsy; P, postmortem. Staining: 0, less than 10% of tumour cells stained; 1, 10–39% of tumour cells stained; 2, 40–79% of tumour cells stained; 3, 80–100% of tumour cells stained; C, cytoplasmic staining; M, membranous staining; N, nuclear staining. VIM, anti-vimentin; TM, anti-thrombomodulin; CAL, anti-calretinin; CEA, anti-carcinoembryonic antigen; EMA, anti-epithelial membrane antigen.
1B Epithelioid 3C 0 1M 0 2C/N 0 1N 0 0 0 1M 2N
1P Epithelioid 3C 0 2M 0 1C 0 0 0 0 0 2M 2N
2B Epithelioid 3C 0 0 1M 0 1M 0 0 0 0 3M 2N
2P Epithelioid 3C 0 2M 0 0 2M 0 1C 0 2M 2M 0
3B Epithelioid 3C 0 1M 1M 2C/N 3M 3N 0 0 0 1M 2N
3P Epithelioid 3C 0 2M 1M 0 2M 1N 0 0 0 1M 1N
4B Epithelioid 3C 0 1M 1M 2C/N 2M 1N 0 0 0 2M 3N
4P Epithelioid 3C 0 3M 1M 0 0 0 0 0 2M 2M 1N
5B Biphasic 3C 0 2M 0 3C/N 2M 2N 0 0 0 3M 1N
5P Epithelioid 3C 0 3M 0 2C 0 0 0 0 2M 3M 0
6B Sarcomatoid 3C 3C 0 0 0 3M 0 0 0 0 1M 2N
6P Sarcomatoid 3C 1C 0 0 0 2M 0 0 0 0 1M 0
7B Sarcomatoid 2C 3C 0 0 0 2M 0 0 0 0 0 1N
7P Sarcomatoid 3C 3C 0 0 0 0 0 0 0 0 1M 0
8B Sarcomatoid 2C 3C 0 0 0 3M 0 0 0 0 2M 2N
8P Sarcomatoid 3C 3C 0 0 0 3M 0 0 0 0 2M 2N
9B Sarcomatoid 0 3C 0 0 0 3M 0 0 0 0 0 3N
9P Sarcomatoid 0 2C 0 0 0 3M 0 0 0 0 0 1N

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