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J Clin Pathol 53:282-285 doi:10.1136/jcp.53.4.282

Estimating antemortem drug concentrations from postmortem blood samples: the influence of postmortem redistribution

Table 1

Comparison of postmortem peripheral blood (PM)/perimortem (AM) plasma ratios with C/P ratios for a selection of drugs

Drug PM/AM C/P‡ C/P range‡
‡From Dalpe-Scott et al, 1995.21
*Calculated from the specific case.
C/P, central to peripheral ratio.
Dothiepin 11.7 2.2*
Dextropropoxyphene 8.3 3.2 0.9–7.3
Amitriptyline 3.9 2.9 0.9–13.9
Methadone 2.6 2.6*
Propranolol 1.9 2.5 1.0–3.8
Paracetamol 1.5 1.3 0.7–2.8
Salicylate 1.0 1.3 0.5–3.9

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