Polymorphous low grade adenocarcinoma with distant metastases and deletions on chromosome 6q23–qter and 11q23–qter: a case report
- 1Department of Oral and Maxillofacial Surgery, University Hospital Nijmegen, PO Box 9101, 6500 HB Nijmegen, The Netherlands
- 2Department of Pathology, University Hospital Nijmegen
- 3Department of Pulmonology, University Hospital Nijmegen
- Dr Hannen, Department of Cranio-Maxillofacial Surgery, University Hospital Maastricht, PO Box 5800, 6202 AZ Maastricht, The Netherlands ehan{at}mkg.azm.nl
- Accepted 10 April 2000
Abstract
Polymorphous low grade adenocarcinomas (PLGAs) are thought to be indolent tumours that are localised preferentially to the palate and affect the minor salivary glands almost exclusively. Metastases to locoregional lymph nodes occur in only 6–10% of cases. Recently, two cases of PLGA with microscopically confirmed distant metastases have been reported. This study reports a third case of PLGA with histologically and immunohistochemically confirmed distant metastases. It is the first case with multiple pleural, as well as pulmonary parenchymal, metastases and metastases in cervical and para-oesophageal lymph nodes. In most cases, PLGAs are salivary gland tumours with limited potential to metastasise and a good prognosis after local treatment. However, the recently reported cases reveal that the tumour can give rise to widely spread metastases. To obtain more information about the incidence of distant metastases, periodic chest x ray examination during follow up is desirable.
- polymorphous low grade adenocarcinoma
- neoplasm metastasis
- comparative genomic hybridisation
- human chromosome pair 6
- human chromosome pair 11
