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J Clin Pathol 2000;53:940-941 doi:10.1136/jcp.53.12.940

Chronic myeloid leukaemia occurring in a patient with hairy cell leukaemia

  1. F A Wandroo1,
  2. D Bareford1,
  3. F El-Jehani1
  1. 1Department of Haematology, City Hospital NHS Trust, Dudley Road, Birmingham B18 7QH, UK
  1. Dr Wandroo, Department of Haematology, Mid Staffordshire General Hospital, Stafford ST16 3SA, UK a.w.farooq{at}tinyonline.co.uk
  • Accepted 28 April 2000

Abstract

Occurrences of second malignancies in hairy cell leukaemia are well recognised. Most of these malignancies are either solid tumours or lymphoproliferative disorders. The association of myeloproliferative disorders with hairy cell leukaemia (HCL) is very rare. This report describes a case of a patient with HCL who after remaining in remission developed Philadelphia chromosome positive chronic myeloid leukaemia (CML), which rapidly transformed to acute lymphoblastic leukaemia with further cytogenetic abnormalities.

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