Table 5
Somatic mutations of hMSH2 and hMLH1 genes in microsatellite instability (MSI) high cases
| Case | Gene | Affected codon | DNA change | Nomenclature of mutation |
|---|---|---|---|---|
| Sequence accession numbers by Genebank (hMLH1, U07418; hMSH2, U03911). | ||||
| ins, insertion. | ||||
| 72 | hMSH2 | 754 | ins G | Frameshift to stop at 786 |
| 78 | hMLH1 | 163 | TAC-TAA | Nonsense |
| 148 | hMLH1 | 179 | ins G | Frameshift to stop at 197 |
| 151 | hMLH1 | 291 | TTG-TAG | Nonsense |
| 121 | hMLH1 | 425 | GAT-GGT | Missense from Asp to Gly |
| 102 | hMLH1 | 320 | ins C | Frameshift to stop at 361 |
