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Inter-disciplinary |
1 Imperial College London, United Kingdom
* To whom correspondence should be addressed. E-mail: c.palmieri{at}imperial.ac.uk.
Accepted 23 August 2006
 | Abstract |
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Background: Laboratory and epidemiological studies have implicated vitamin D deficiency in the pathogenesis of breast cancer. 1,25-dihydroxyvitamin D (1,25(OH)2D) promotes differentiation and apoptosis, and potently inhibits proliferation of malignant breast epithelial cells in culture. It has previously been shown that serum levels of 1,25(OH)2D are higher in normal women compared to patients with primary breast cancer. This study aims to clarify the role of vitamin D in breast cancer progression by comparing the levels of serum vitamin D in patients with early and advanced breast cancer.
Methods: Circulating levels of 25 hydroxyvitamin D 25(OH)D, parathyroid hormone (PTH), and calcium were measured in 279 caucasian women with invasive breast cancer, 204 with early stage malignancy and 75 with locally advanced or metastatic disease.
Results: Patients with early stage breast cancer had significantly higher circulating levels of 25(OH)D (P=0.0049) and significantly lower PTH (P=0.0001) levels compared to those with advanced disease. Calcium levels did not differ significantly (p=0.74).
Conclusion: Serum levels of 25(OH)D are significantly higher in patients with early stage breast cancer compared to those with locally advanced and/or metastatic disease.
Key Words: Breast Cancer, Calcium, PTH, Vitamin D
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