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Figure 3 (A) In contrast with low-grade dysplasia (LGD), high-grade dysplasia (HGD) shows crowded crypts with more severe nuclear stratification. The nuclei reach the luminal surface in the deeper portions of the crypts. In addition, there is mild architectural distortion. On high-power view (B), the nuclei have a slightly more open chromatin pattern with prominent, sometimes multiple, nucleoli and a more marked loss of cell polarity. The nuclear/cytoplasmic ratio of HGD is markedly increased compared with LGD.
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