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HDL-cholesterol and triglycerides: an overlooked issue?

Department of Clinical Biochemistry, The Ipswich Hospital, Heath Road, Ipswich, Suffolk IP4 5PD, UK

Correspondence to:
Dr Patrick J Twomey
Department of Clinical Biochemistry, The Ipswich Hospital, Heath Road, Ipswich, Suffolk IP4 5PD, UK; patrick.twomey@ipswichhospital.nhs.uk 31 January 2006

Keywords: CHD risk; HDL-C; accuracy; total error; tryglycerides

The first 150 words of the full text of this article appear below.

Several prospective clinical trials and epidemiological studies have shown that a low concentration of high-density lipoprotein-cholesterol (HDL-C) is an independent risk factor for coronary heart disease (CHD).^1,2 It is estimated that for every 0.0259 mmol/l decrease in HDL-C, the relative risk of CHD events increases by 2–3%.³ Accordingly, HDL-C determinations are included in CHD prevention programmes.⁴ Reliable and easy to perform HDL-C assays are therefore required for routine laboratory practice.

There is often an inverse relationship between HDL-C and triglyceride concentrations. Accordingly, specimens with a low HDL-C often have a raised triglyceride concentration. HDL-C assay manufacturers often recommend dilution when the triglyceride is above a particular concentration. We decided to evaluate our routine HDL-C method to assess what triglyceride cut-off we should routinely utilise before specimen dilution.

HDL-C concentrations were determined using an anti human-ß-lipoprotein antibody that binds to non-HDL lipoproteins and allows the quantification of HDL-C by the presence . . . [Full text of this article]