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Multiple congenital infantile hemangiomas of the lung in partial trisomy D

Department of Pathology, Children’s Hospital "Superiora Sor Maria Ludovica", La Plata, Argentina

Correspondence to:
G Quijano
Department of Pathology, Children’s Hospital "Superiora Sor Maria Ludovica", 1900 La Plata, Argentina; patologi@netverk.com.ar 25 October 2005

The first 150 words of the full text of this article appear below.

The postmortem examination of a multimalformed infant with trisomy D revealed 33 capillary hemangiomas in both lungs, with the microscopic features of the common cutaneous GLUT-1 infantile hemangioma. The finding further expands the spectrum of sites where this type of capillary hemangioma can be found, as it has been reported in the placenta, liver, salivary gland and mammary gland. Its association with the genetic condition trisomy D, already known to occasionally present cutaneous and hepatic hemangiomas, could be a clue to its pathogenesis.

Hemangiomas in children are most commonly recognised in the skin and liver. They are infrequent in the respiratory tract, presenting predominantly in the subglottic region, and extremely rare in the lung. Pulmonary hemangiomas include endobronchial and parenchymatous types. In accordance to its structure, they are classified as capillary and cavernous histological types.¹

Among the angiomatous lesions of childhood, the so-called infantile hemangioma (IH) shows a peculiar characteristic: . . . [Full text of this article]