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Coeliac disease

¹ First Department of Medicine, IRCCS Policlinico S. Matteo University of Pavia, Pavia I-27100, Italy
² Second Department of Pathology, Spedali Civili di Brescia, Brescia I-25100, Italy

Correspondence to:
Dr V Villanacci
Second Department of Pathology, Spedali Civili di Brescia, Brescia I-25100, Italy; villan@iol.it

Keywords: coeliac disease; histology; lymphocytes

The first 150 words of the full text of this article appear below.

Coeliac disease (CD) is a gluten dependent enteropathy with a very high prevalence¹ and an increased mortality rate.² Our knowledge regarding the clinical and pathogenetic aspects of CD has increased considerably over the past few years, but its diagnosis today—like several decades ago—is still based on the biopsy confirmed presence of duodenal–jejunal mucosal lesions that improve after a gluten free diet.

Although the greatest diagnostic challenge in CD concerns the identification of patients to be subjected to intestinal biopsy, rather than the choice of histopathological criteria, it is believed that the currently used criteria³ are often the source of disagreement between pathologists and clinicians and, at times, of misdiagnosis for the patients.

Based on the dynamic development pattern of coeliac lesions and on the frequent finding of cases of CD with mild lesions, Marsh³ proposed a four stage grading, namely: (1) type 1 infiltrative lesions, characterised by normal . . . [Full text of this article]

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				B C Dickson, C J Streutker, and R Chetty Coeliac disease: an update for pathologists. J. Clin. Pathol., October 1, 2006; 59(10): 1008 - 1016. [Abstract] [Full Text] [PDF]

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