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CCN workshop

¹ Center for Cell and Vascular Biology, Children’s Research Institute, Columbus, Ohio 43016, USA
² Department of Biochemistry and Molecular Genetics, University of Illinois Colleage of Medicine, Chicago, IL 60607, USA
³ Laboratoire d’Oncologie Virale et Moléculaire - UFR de Biochimie, Université Paris 7 - D. Diderot, 2 Place Jussieu 75005 Paris, France

Correspondence to:
Professor B Perbal
Laboratoire d’Oncologie Virale et Moléculaire - UFR de Biochimie, Université Paris 7 - D. Diderot, 2 Place Jussieu 75005 Paris, France; perbal@ccr.jussieu.fr

Keywords: cancer; differentiation; proliferation; signalling

The first 150 words of the full text of this article appear below.

The CCN family currently comprises six extracellular matrix associated proteins (CCN1–6) that regulate diverse cell functions. Although CCN molecules regulate vital processes in vivo (for example, chondrogenesis, angiogenesis, and matrix remodelling) and are associated with several pathophysiological disorders (such as fibrosis and tumorigenesis), it has been a challenge to define the underlying biological mechanisms involved. Progress has been hampered by the disparate in vivo and in vitro models used by investigators in the field, and by the difficulty in obtaining validated reagents (particularly recombinant CCN proteins) for experimental use. In spite of these drawbacks, there have been many exciting developments in the field over the past few years, and it was against this backdrop that investigators convened for the Third International Workshop on the CCN Family of Genes in St Malo, France on 20–23 October 2004.

GENE EXPRESSION
Although studies in the early 1990s showed that CCN1 and CCN2 were . . . [Full text of this article]