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Tissue grading system is a reliable assay of response to treatment in gastric MALT lymphoma

A histological grading system for gastric MALT lymphoma after treatment looks to be a promising tool for assessing residual disease in prospective drug trials. A pilot study has confirmed that the system has good internal reproducibility.

Good agreement was achieved among the scores of seven histopathologists who separately scored 45 sets of stained gastric biopsies for three criteria—lymphoid infiltrate, lymphoepithelial lesions, and stromal changes—from 10 patients treated for gastric MALT lymphoma. The results translated into four clinically meaningful scores: complete histological remission, probable minimal residual disease, responding residual disease, and no change.

The 10 patients comprised seven men and three women enrolled in one arm of a multicentre clinical trial of gastric MALT lymphoma and selected randomly. They had been treated to eradicate Helicobacter pylori and were followed up for a mean of 19 months, during which three to six sequential gastric biopsies were obtained. The histopathologists were blinded to . . . [Full text of this article]