HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jcp.2008.055699v1 61/8/885    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Google Scholar Articles by Alldredge, B PubMed PubMed Citation Articles by Alldredge, B

Clinical connexions

Correspondence to:
Brett Alldredge, Brigham Young University, PDBIO, 574 WIDB, Provo, UT 84602, USA; brett_alldredge{at}byu.net

The past decade of scientific research has seen a proliferation of information regarding the identification and biophysical properties of gap junctions and their constituents, connexin proteins. Advances in biological research techniques have elucidated a ubiquitous distribution and dynamic regulation of connexins and gap junctions. The gap junction is the primary component of the electrical synapse that couples cells together morphologically and functionally. The importance of gap junctions to homeostasis is reflected by the observance of their dysfunction in a myriad of pathologies. Singular studies noting an aetiological association of connexins and gap junctions in pathologies have also been rapidly accumulating. This paper will circumscribe these studies of pathology and connexins to review their clinical implications.