Journal of Clinical Pathology 2008;61:377-381
ORIGINAL ARTICLES
Duodenal follicular lymphomas share common characteristics with mucosa-associated lymphoid tissue lymphomas
Department of Pathology, Okayama University Graduate School of Medical, Dentistry and Pharmaceutical Sciencies, Okayama, Japan
Correspondence to:
Dr Tadashi Yoshino, Department of Pathology, Okayama University Graduate School of Medicine, Dentistry and Pharmaceutical Sciences, 2-5-1 Shikata-cho, Okayama 700-8558, Japan; yoshino{at}md.okayama-u.ac.jp
Background: Follicular lymphomas occasionally arise in the extra-nodal organs and are frequently found in the duodenum. They are often localised tumours with multiple polyps around the ampulla of Vater.
Aims: To examine a IgH/bcl-2 hybrid gene and VH gene to investigate the nature of the lymphoma cells and how they differ from nodal follicular lymphomas and MALT lymphomas.
Methods: Of 40 patients reported previously, 35 with duodenal follicular lymphoma were studied in detail with respect to clinicopathological characteristics.
Results: 37/40 patients were in clinical stage I (n = 30) or stage II (n = 7). Clonal immunoglobulin gene rearrangement was detected in 53.3% of examined cases, and rearrangement of IgH/bcl-2 gene at the major break point was detected in 27% of cases. Three of 8 examined cases were VH4 (38%); 2 out of them were VH4-34. As VH4 deviation is one of the common characteristics of MALT lymphomas and 2/3 were identical, duodenal follicular lymphomas have a similar aetiology to MALT lymphomas. Clinical course was also similar to that of MALT lymphomas.
Conclusions: Results suggest that duodenal follicular lymphomas have intermediate characteristics of MALT lymphomas and nodal follicular lymphomas.
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
This article has been cited by other articles:
-
Sentani, K., Maeshima, A. M., Nomoto, J., Maruyama, D., Kim, S.-W., Watanabe, T., Kobayashi, Y., Tobinai, K., Matsuno, Y.
(2008). Follicular Lymphoma of the Duodenum: A Clinicopathologic Analysis of 26 Cases. Jpn J Clin Oncol
0: hyn069v1-6
[Abstract] [Full Text]
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jcp.2007.049825v1
jcp.2007.049825v2
61/3/377 most recent - Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
- PubMed Citation
- Articles by Sato, Y
- Articles by Yoshino, T
- Pubmed/NCBI databases
Medline Plus Health Information 
Intestinal Cancer
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
