Journal of Clinical Pathology 2008;61:84-88
ORIGINAL ARTICLES
Immune factors involved in the cervical immune response in the HIV/HPV co-infection
1 Laboratory of Immunopathology, Instituto Oswaldo Cruz – DBBM, Fiocruz, Rio de Janeiro, Brazil
2 Department of Pathology, University Hospitals, Columbus, Ohio, USA
3 Department of Infectious Disease of Evandro Chagas Clinical Research Institute, Fiocruz, Rio de Janeiro, Brazil
4 Fernandes Figueira Institute, Fiocruz, Rio de Janeiro, Brazil
5 Multidisciplinary Laboratory, Clementino Fraga Filho University Hospital, Federal University of Rio de Janeiro, Rio de Janeiro, Brazil
Correspondence to:
Alcina F Nicol, Laboratory of Immunopathology – DBBM – IOC/Fiocruz, Rio de Janeiro, RJ- Av. Brasil 4365 Manguinhos, Brazil; nicol{at}ioc.fiocruz.br
Aims: Immune factors influencing the progression of cervical intraepithelial neoplasia (CIN) to cancer remain poorly defined. This study investigates the expression of RANTES, MIP1
, COX1, COX2, STAT3, TGFβRI, IL10R, TNFRII and TLR4 in the cervical immune response in HIV/HPV (human papillomavirus) co-infected women.
Methods: Cervical biopsies of 36 patients were assayed by immunohistochemistry, and the Ventana Benchmark System was used for HIV-nef detection.
Results: Cervices from HIV-positive patients exhibited nef in cells mainly around blood vessels, and showed a decreased expression of all the immune factors tested except IL10R and STAT3, while RANTES (5.54 cells/mm2) was highly expressed in comparison with controls (1.41 cells/mm2, p = 0.028). COX1 was decreased in the HIV/HPV- (0.32 cells/mm2, p = 0.017) and HPV-infected patients (0.21 cells/mm2, p = 0.015) compared with controls (3.28 cells/mm2).
Conclusions: It is suggested that RANTES in HIV/HPV co-infection may influence the development of CIN leading to progression to cervical cancer.
Keywords: RANTES; cervix; immune factors; cyclooxygenases; HIV-1/HPV
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