Journal of Clinical Pathology 2007;60:307-310
ORIGINAL ARTICLE
Expression of peroxisome proliferator activated receptor 
and cyclo-oxygenase 2 in primary and recurrent ovarian carcinoma
1 Institute of Pathology, University Hospital Basel, Basel, Switzerland
2 Department of Gynecology and Obstetrics, University Hospital Basel, Basel, Switzerland
3 Institute of Pathology, University of Regensburg, Regensburg, Germany
Correspondence to:
Correspondence to:
PD Dr G Singer
Institute of Pathology, University Hospital Basel, Schönbeinstrasse 40, CH-4031 Basel, Switzerland; gsinger{at}uhbs.ch
Aim: Peroxisome proliferator-activated receptor 
(PPAR) has emerged as a potential therapeutic target in several types of cancer. In ovarian carcinomas, limited and conflicting data on PPAR protein expression have been reported.
Methods: The immunoexpression of PPAR and its putative target cyclo-oxygenase 2 (COX2) was investigated in tumour tissues from 80 patients with primary and corresponding recurrent ovarian serous carcinomas after conventional platinum-based chemotherapy.
Results: PPAR expression was observed in 29% of primary and recurrent carcinomas. In the recurrent tumours, PPAR expression inversely correlated with COX2 overexpression in both chemosensitive (p = 0.02) and chemoresistant (p = 0.04) carcinomas.
Conclusions: The data indicate that PPAR may represent a potential target for second-line treatment in ovarian cancers.
Abbreviations: COX2, cyclo-oxygenase 2; IHC, immunohistochemistry; PPAR, peroxisome proliferator-activated receptor ; TMA, tissue microarray
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