VIRUSES AND LYMPHOMAS
Kaposi sarcoma-associated herpesvirus/human herpesvirus 8 and lymphoproliferative disorders
1 Department of Pathology, University of Cambridge, Cambridge, UK
2 Department of Histopathology, University College London, UK
Correspondence to:
Professor Ming-Qing Du, Division of Molecular Histopathology, Department of Pathology, University of Cambridge, Box 231, Level 3, Lab Block, Addenbrooke’s Hospital, Hills Road, Cambridge CB2 2QQ, UK; mqd20{at}cam.ac.uk
Kaposi sarcoma-associated herpesvirus (KSHV), also known as human herpesvirus 8 (HHV8), is a recent addition to the list of human viruses that are directly associated with lymphoproliferative disorders. KSHV was first shown to be involved in multicentric Castleman disease and primary effusion lymphoma (PEL). Subsequently, the virus was identified in solid lymphomas, often of extranodal sites, with morphological and immunophenotypic characteristics similar to those of PEL, and in other lymphoproliferative disorders with heterogeneous clinicopathological presentations. The recent advances in our understanding of the histology, immunophenotype and pathogenesis of these KSHV-associated lymphoproliferative disorders are reviewed.
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