Journal of Clinical Pathology 2007;60:1254-1262
ORIGINAL ARTICLES
Endoscopic ultrasound guided fine needle aspiration of non-pancreatic lesions: an institutional experience
1 Department of Pathology and Laboratory Medicine, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
2 Department of Medicine, Gastroenterology Division, University of Pennsylvania Medical Center, Philadelphia, Pennsylvania, USA
Correspondence to:
Dr Zubair W Baloch, Department of Pathology and Laboratory Medicine, 6 Founders Pavilion, University of Pennsylvania Medical Center, 3400 Spruce Street, Philadelphia, PA 19104, USA; baloch{at}mail.med.upenn.edu
Background: Endoscopic ultrasound guided fine needle aspiration biopsy (EUS-FNA) has proven to be an effective diagnostic modality for the detection and staging of pancreatic malignancies. In recent years EUS-FNA has also been used to diagnose lesions of non-pancreatic sites such as structures in close proximity to the gut wall within the mediastinum, abdomen, pelvis and retro-peritoneum.
Aims: To evaluate experience with EUS-FNA of non-pancreatic sites at a large university medical centre.
Methods: The study cohort included 234 patients who underwent EUS-FNA of 246 lesions in non-pancreatic sites (122 peri-pancreatic and coeliac lymph nodes; 9 peri-pancreatic masses; other sites: mediastinum 12, gastric 25, liver 27, oesophagus 17, duodenum/colon/rectum 15, retro-peritoneum 8, lung 7, miscellaneous 4).
Results: The cytology diagnoses were classified as non-neoplastic/reactive in 82 (33%), atypical/suspicious for malignancy in 25 (10%), malignant in 86 (35%) and non-diagnostic in 53 (22%) cases. Surgical pathology follow-up was available in 75 (31%) cases. Excluding the non-diagnostic cases there were 7 false negative and 3 false positive cases. The sensitivity, specificity and positive predictive value of EUS-FNA in the diagnosis of lesions of non-pancreatic sites was 92%, 98% and 97%, respectively.
Conclusions: EUS-FNA can be effectively used as a diagnostic modality in the diagnosis of lesions from non-pancreatic sites.
Abbreviations: EUS, endoscopic ultrasound; FNA, fine needle aspiration; GI, gastrointestinal; GIST, gastrointestinal stromal tumour
Keywords: endoscopy; ultrasound; fine needle biopsy
![]()
CiteULike
Complore
Connotea
Del.icio.us
Digg
Reddit
Technorati What's this?
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
