HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jcp.2006.044222v1 60/10/1092    most recent Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Atayar, C. Articles by Poppema, S. Search for Related Content PubMed PubMed Citation Articles by Atayar, C. Articles by Poppema, S. Pubmed/NCBI databases Medline Plus Health Information Hodgkin's Disease

Hodgkin’s lymphoma associated T-cells exhibit a transcription factor profile consistent with distinct lymphoid compartments

Çidem Atayar

¹ Department of Pathology & Laboratory Medicine, University of Groningen and University Medical Centre Groningen, The Netherlands
² Department of Pathology, University of British Columbia and British Columbia Cancer Agency, Vancouver, BC, Canada

Correspondence to:
Professor Sibrand Poppema, Department of Pathology & Laboratory Medicine, University Medical Centre Groningen, Hanzeplein 1, PO Box 30.001, 9700 RB Groningen The Netherlands; s.poppema{at}rvb.umcg.nl

Background: Hodgkin’s lymphoma (HL) is characterised by an ineffective immune response that is predominantly mediated by CD4⁺ T-cells.

Aims: To analyse the expression of the key regulatory T-cell transcription factors (TFs) in the T-cells of HL involved tissues in order to assess the nature of the T_H immune response in HL.

Methods and results: By immunohistochemistry, GATA3 was strongly and T-bet exclusively expressed in a subset of interfollicular lymphocytes in the reactive lymphoid tissues. In classical HL (CHL), which is generally located in the interfollicular zones, a predominance of T-bet⁺ T-cells and lesser amounts of GATA3⁺ and c-Maf⁺ T-cells was found, concordant with the pattern of the normal interfollicular compartment. In reactive lymphoid tissues, c-Maf was observed mostly in T-lymphocytes within the germinal centres (GCs). Nodular lymphocyte predominance type of Hodgkin’s lymphoma (NLPHL) and progressively transformed germinal centres cases, showed a majority of c-Maf⁺ T-cells, consistent with the pattern in normal GCs. NLPHL cases uniformly showed c-Maf⁺/CD57⁺ T-cell rosettes around the neoplastic cells; these rosettes were absent in "paragranuloma-type" T-cell/histiocyte rich B-cell lymphoma.

Conclusions: T-cell TF expression profiles of the reactive T-cells in both subtypes of HL are in accordance with the expression profile observed in the distinct lymphoid compartments.

Abbreviations: CHL, classical Hodgkin’s lymphoma; GC, germinal centre; HL, Hodgkin’s lymphoma; HRBCL, histiocyte rich B-cell lymphoma; HRS, Hodgkin and Reed–Sternberg; L&H, lymphocytic and/or histiocytic; NLPHL, nodular lymphocyte predominance type of Hodgkin’s lymphoma; PTGC, progressively transformed germinal centre; TF, transcription factor; T_H, T-helper

Keywords: Hodgkin’s lymphoma; nodular lymphocyte predominance type of Hodgkin’s lymphoma; progressive transformation of germinal centres; T-cell transcription factors; T-helper cells