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Nodal aggressive B-cell lymphomas: a diagnostic approach

Division of Hematopathology, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA

Correspondence to:
Dr Steven H Swerdlow, Division of Hematopathology, University of Pittsburgh School of Medicine, UPMC-Presbyterian, Room C606, 200 Lothrop Street, Pittsburgh, PA 15213, USA; swerdlowsh{at}upmc.edu

ABSTRACT
The diffuse aggressive B-cell lymphomas, as recognised in the 2001 WHO classification, represent a clinically and biologically heterogeneous group of neoplasms that require very different therapeutic approaches and have very different outcomes. They should be diagnosed using a multiparameter approach that emphasises morphological and immunophenotypic studies, and in at least some cases, relies on cytogenetic and/or genotypic studies. Incorporation of clinical data may be important as well. There is also current interest in going beyond the basic diagnosis and providing pathological prognostic information when possible. Whereas the diagnosis of some cases will be relatively easy, the differential diagnosis in others is very difficult, with some cases in a grey zone between two different well defined categories.

Keywords: aggressive B-cell lymphoma; B-cell lymphoma; Burkitt lymphoma; diffuse large cell lymphoma; high grade B-cell lymphoma