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Journal of Clinical Pathology 2007;60:18-26; doi:10.1136/jcp.2005.035592
Copyright © 2007 by the BMJ Publishing Group Ltd & Association of Clinical Pathologists.

REVIEW

Distinguishing diabetic nephropathy from other causes of glomerulosclerosis: an update

K O Alsaad and A M Herzenberg

Department of Laboratory Medicine and Pathobiology, University of Toronto, University Health Network, Toronto, Ontario, Canada

Correspondence to:
Correspondence to:
Dr A M Herzenberg
Princess Margaret Hospital, UHN, Room 4-302, 610 University Avenue, Toronto, Canada, M5G 2M9; andrew.herzenberg{at}uhn.on.ca

ABSTRACT

Diabetic nephropathy is a common cause of end-stage renal disease worldwide. It is characterised by diffuse or nodular glomerulosclerosis, afferent and efferent hyaline arteriolosclerosis, and tubulointerstitial fibrosis and atrophy. Diffuse and nodular diabetic glomerulosclerosis share similar histological features with other clinical conditions. Immunofluorescence and electron microscopy studies, and clinicopathological correlation are essential to differentiate diabetic nephropathy from other conditions that result in diffuse and nodular glomerulosclerosis.

Abbreviations: GBM, glomerular basement membrane; ING, idiopathic nodular glomerulosclerosis; MIDD, monoclonal immunoglobulin deposition disease; PAS, periodic acid Schiff; TBM, tubular basement membrane


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This article has been cited by other articles:

  • Qian, Y., Feldman, E., Pennathur, S., Kretzler, M., Brosius, F. C. III (2008). From Fibrosis to Sclerosis: Mechanisms of Glomerulosclerosis in Diabetic Nephropathy. Diabetes 57: 1439-1445 [Full Text]  

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