CASE REPORT
Interferon 
sensitisation induced fatal renal insufficiency in a patient with chronic myeloid leukaemia: case report and review of literature
1 Institute of Haematology, School of Medicine, University of Belgrade, Serbia
2 School of Medicine, University of Kragujevac, Kragujevac, Serbia and Montenegro
3 Medical Military Academy Crnotravska, Belgrade, Serbia and Montenegro
Correspondence to:
Correspondence to:
Professor Vladimir Jurisic
University of Kragujevac, School of Medicine, PO Box 124, 34000 Kragujevac, Serbia, Serbia and Montenegro; vdvd{at}mailcity.com
Renal dysfunction as a sequel to extended interferon alfa (IFN
) treatment in chronic myeloid leukaemia (CML) has been reported previously in six patients. An additional patient is presented with Philadelphia chromosome positive (Ph+) CML and nephrotic syndrome in whom initial renal insufficiency developed after only one month of low dose IFN therapy. The renal biopsy showed a focal segmental mononuclear cell infiltration, basal membrane thickening, and deposits of immunoglobulins (IgG; IgAGM IC3). In spite of discontinuation of IFN, renal function deteriorated and the patient died six months later. This case represents an instance of fatal kidney insufficiency as an untoward effect of sensitisation to the IFN, confirmed by modified Coombs assay.
Abbreviations: CML, chronic myeloid leukaemia; IFN, interferon
Keywords: interferon alpha; chronic myeloid leukaemia; nephrotic syndrome
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