HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) All Versions of this Article: jcp.2005.033043v1 59/7/729    most recent Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Banerjee, S Articles by Smith, I E Search for Related Content PubMed PubMed Citation Articles by Banerjee, S Articles by Smith, I E

Basal-like breast carcinomas: clinical outcome and response to chemotherapy

¹ Breast Unit, Royal Marsden Hospital, London, UK
² The Breakthough Breast Cancer Research Centre, Institute of Cancer Research, London
³ Life and Health Sciences Research Institute (ICVS), University of Minho, Braga, Portugal
⁴ Department of Computing, Royal Marsden Hospital, Sutton, UK
⁵ Molecular and Cellular Pathology, School of Medicine, The University of Queensland, Mayne Medical School, Herston, Australia

Correspondence to:
Professor I E Smith
Breast Unit, Royal Marsden Hospital, Fulham Road, London SW3 6JJ, UK; ian.smith{at}rmh.nhs.uk Background: Grade-III invasive ductal carcinomas of no special type (IDCs-NST) constitute a heterogeneous group of tumours with different clinical behaviour and response to chemotherapy. As many as 25% of all grade-III IDCs-NST are known to harbour a basal-like phenotype, as defined by gene expression profiling or immunohistochemistry for basal cytokeratins. Patients with basal-like breast carcinomas (BLBC) are reported to have a shorter disease-free and overall survival.

Material and methods: A retrospective analysis of 49 patients with BLBC (as defined by basal cytokeratin expression) and 49 controls matched for age, nodal status and grade was carried out. Histological features, immunohistochemical findings for oestrogen receptor (ER), progesterone receptor (PgR) and HER2, and clinical outcome and survival after adjuvant chemotherapy were compared between the two groups.

Results: It was more likely for patients with BLBCs to be found negative for ER (p<0.0001), PgR (p<0.0001) and HER2 (p<0.01) than controls. Patients with BLBCs were found to have a significantly higher recurrence rate (p<0.05) and were associated with significantly shorter disease-free and overall survival (both p<0.05). In the group of patients who received anthracycline-based adjuvant chemotherapy (BLBC group, n = 47; controls, n = 49), both disease-free and overall survival were found to be significantly shorter in the BLBC group (p<0.05).

Conclusions: BLBCs are a distinct clinical and pathological entity, characterised by high nuclear grade, lack of hormone receptors and HER2 expression and a more aggressive clinical course. Standard adjuvant chemotherapy seems to be less effective in these tumours and new therapeutic approaches are indicated.

Abbreviations: BLBC, basal-like breast carcinoma; Ck, cytokeratin; EGFR, epidermal growth factor receptor; ER, oestrogen receptor; IDCs-NST, invasive ductal carcinomas of no special type; PgR, progesterone receptor

This article has been cited by other articles:

				A. A. Luck, A. J. Evans, J. J. James, E. A. Rakha, E. C. Paish, A. R. Green, and I. O. Ellis Breast Carcinoma with Basal Phenotype: Mammographic Findings Am. J. Roentgenol., August 1, 2008; 191(2): 346 - 351. [Abstract] [Full Text] [PDF]

				R A Walker Immunohistochemical markers as predictive tools for breast cancer J. Clin. Pathol., June 1, 2008; 61(6): 689 - 696. [Abstract] [Full Text] [PDF]

				E. A. Rakha, J. S. Reis-Filho, and I. O. Ellis Basal-Like Breast Cancer: A Critical Review J. Clin. Oncol., May 20, 2008; 26(15): 2568 - 2581. [Abstract] [Full Text] [PDF]

				E Korsching, S S Jeffrey, W Meinerz, T Decker, W Boecker, and H Buerger Basal carcinoma of the breast revisited: an old entity with new interpretations J. Clin. Pathol., May 1, 2008; 61(5): 553 - 560. [Abstract] [Full Text] [PDF]

				Y. Eralp, D. Derin, Y. Ozluk, E. Yavuz, N. Guney, P. Saip, M. Muslumanoglu, A. Igci, S. Kucucuk, M. Dincer, et al. MAPK overexpression is associated with anthracycline resistance and increased risk for recurrence in patients with triple-negative breast cancer Ann. Onc., April 1, 2008; 19(4): 669 - 674. [Abstract] [Full Text] [PDF]

				M. C.U. Cheang, D. Voduc, C. Bajdik, S. Leung, S. McKinney, S. K. Chia, C. M. Perou, and T. O. Nielsen Basal-Like Breast Cancer Defined by Five Biomarkers Has Superior Prognostic Value than Triple-Negative Phenotype Clin. Cancer Res., March 1, 2008; 14(5): 1368 - 1376. [Abstract] [Full Text] [PDF]

				J. Winter Morphological and immunophenotypic analysis of basal-like carcinoma of the breast Bioscience Horizons, March 1, 2008; 1(1): 19 - 27. [Abstract] [Full Text] [PDF]

				S. Lu, K. Simin, A. Khan, and A. M. Mercurio Analysis of Integrin {beta}4 Expression in Human Breast Cancer: Association with Basal-like Tumors and Prognostic Significance Clin. Cancer Res., February 15, 2008; 14(4): 1050 - 1058. [Abstract] [Full Text] [PDF]

				L Da Silva, C Clarke, and S R Lakhani Demystifying basal-like breast carcinomas J. Clin. Pathol., December 1, 2007; 60(12): 1328 - 1332. [Abstract] [Full Text] [PDF]

				D. Wienke, G. C. Davies, D. A. Johnson, J. Sturge, M. B.K. Lambros, K. Savage, S. E. Elsheikh, A. R. Green, I. O. Ellis, D. Robertson, et al. The Collagen Receptor Endo180 (CD280) Is Expressed on Basal-like Breast Tumor Cells and Promotes Tumor Growth In vivo Cancer Res., November 1, 2007; 67(21): 10230 - 10240. [Abstract] [Full Text] [PDF]

				K. Altundag, D. S Dede, and T. Purnak Albumin-bound paclitaxel (ABI-007; Abraxane) in the management of basal-like breast carcinoma J. Clin. Pathol., August 1, 2007; 60(8): 958 - 958. [Full Text] [PDF]

				R. Dent, M. Trudeau, K. I. Pritchard, W. M. Hanna, H. K. Kahn, C. A. Sawka, L. A. Lickley, E. Rawlinson, P. Sun, and S. A. Narod Triple-Negative Breast Cancer: Clinical Features and Patterns of Recurrence Clin. Cancer Res., August 1, 2007; 13(15): 4429 - 4434. [Abstract] [Full Text] [PDF]

				L. Verlinden, I. Vanden Bempt, G. Eelen, M. Drijkoningen, I. Verlinden, K. Marchal, C. De Wolf-Peeters, M.-R. Christiaens, L. Michiels, R. Bouillon, et al. The E2F-Regulated Gene Chk1 Is Highly Expressed in Triple-Negative Estrogen Receptor /Progesterone Receptor /HER-2 Breast Carcinomas Cancer Res., July 15, 2007; 67(14): 6574 - 6581. [Abstract] [Full Text] [PDF]

eLetters: