ORIGINAL ARTICLE

A comparison of stent-induced stenosis in coronary and peripheral arteries

K D Krueger¹, A K Mitra², M G DelCore³, W J Hunter, III⁴ and D K Agrawal^2,3

¹ Departments of Medical Microbiology and Immunology, Creighton University School of Medicine, Omaha, Nebraska, USA
² Department of Biomedical Sciences, Creighton University School of Medicine
³ Department of Internal Medicine, Creighton University School of Medicine
⁴ Department of Pathology, Creighton University School of Medicine

Correspondence to:
Correspondence to:
Professor D K Agrawal
Departments of Biomedical Sciences, Medicine, and Medical Microbiology and Immunology, Creighton University School of Medicine, CRISS II Room 510, 2500 California Plaza, Omaha, NE 68178, USA; dkagr{at}creighton.edu

Background and objectives: Restenosis is a complication of interventional procedures such as angioplasty and stenting, often limiting the success of these procedures. Knowledge regarding the relative behaviour of different arteries after these procedures is limited, despite the extensive use of different vascular models. Although the results from studies using different vessels are analysed to predict the behaviour of coronary arteries and other vasculature, direct controlled comparisons between different arteries are necessary for a better understanding of the differential response to restenosis.

Methods: This study examines the response to stenting in coronary and internal iliac arteries as characterised by intimal hyperplasia and restenosis. In a swine model of in-stent stenosis, coronary arteries exhibited higher levels of intimal hyperplasia and per cent stenosis than internal iliac arteries.

Results: After normalisation for injury score, coronary arteries were found to undergo 47% more intimal hyperplasia (p<0.05), whereas per cent stenosis normalised for injury score tended to be higher (p = 0.01). Other measurements reflecting post-stenting intimal hyperplasia (maximal intimal thickness, medial area) did not exhibit significant differences between the artery groups.

Conclusions: These results show that coronary vessels are more prone to develop significant intimal hyperplasia and subsequent restenosis than internal iliac vessels. A better insight into how different arteries and arterial components behave is important in understanding and developing newer and better therapeutic measures for restenosis.

Abbreviations: IEL, internal elastic lamina; IA, intimal area; IS, injury score; MA, medial area; MIT, maximal intimal thickness

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• Murphy, E. H., Arko, F. R. (2008). Karthik S, et al. Cryoplasty for Arterial Restenosis. Eur J Vasc Endovasc Surg. 2007;33:40-43. PERSPECT VASC SURG ENDOVASC THER 20: 98-100 [Abstract]