CASE REPORT

Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript

Y Matsui¹, T Hasegawa², T Kubo¹, T Goto¹, K Yukata¹, K Endo¹, Y Bando³ and N Yasui¹

¹ Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
² Division of Pathology, National Cancer Research Institute, Tokyo, Japan
³ Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Correspondence to:
Correspondence to:
Dr Yoshito Matsui
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; ymatsui{at}sb4.so-net.ne.jp

A 54 year old man developed an unusual lipoma in the patellar tendon, consisting of a fibro-adipose component and a chondro-osseous component. The fibro-adipose component contained mature adipocytes, lipoblasts, and fibroblasts; the chondro-osseous component showed typical endochondral bone formation. Molecular analysis showed that the identical HMGA2-LPP fusion transcript—characteristic of lipoma, parosteal lipoma, and pulmonary chondroid hamartoma—was detectable in the both components.

Keywords: lipoma; chromosomal translocation; RT-PCR; endochondral bone formation

CiteULike    Complore    Connotea    Del.icio.us    Digg    Reddit    Technorati    What's this?

This article has been cited by other articles:

• KUBO, T., MATSUI, Y., NAKA, N., ARAKI, N., GOTO, T., YUKATA, K., ENDO, K., YASUI, N., MYOUI, A., KAWABATA, H., YOSHIKAWA, H., UEDA, T. (2009). Expression of HMGA2-LPP and LPP-HMGA2 Fusion Genes in Lipoma: Identification of a Novel Type of LPP-HMGA2 Transcript in Four Cases. Anticancer Res 29: 2357-2360 [Abstract] [Full Text]