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Intrapatellar tendon lipoma with chondro-osseous differentiation: detection of HMGA2-LPP fusion gene transcript

¹ Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan
² Division of Pathology, National Cancer Research Institute, Tokyo, Japan
³ Department of Molecular and Environmental Pathology, Institute of Health Biosciences, The University of Tokushima Graduate School, Tokushima, Japan

Correspondence to:
Dr Yoshito Matsui
Department of Orthopaedics, Institute of Health Biosciences, The University of Tokushima Graduate School, 3-18-15 Kuramoto-cho, Tokushima 770-8503, Japan; ymatsui{at}sb4.so-net.ne.jp
ABSTRACT
A 54 year old man developed an unusual lipoma in the patellar tendon, consisting of a fibro-adipose component and a chondro-osseous component. The fibro-adipose component contained mature adipocytes, lipoblasts, and fibroblasts; the chondro-osseous component showed typical endochondral bone formation. Molecular analysis showed that the identical HMGA2-LPP fusion transcript—characteristic of lipoma, parosteal lipoma, and pulmonary chondroid hamartoma—was detectable in the both components.

Keywords: lipoma; chromosomal translocation; RT-PCR; endochondral bone formation