Journal of Clinical Pathology 2006;59:1133-1150
MY APPROACH
An approach to duodenal biopsies
Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario, Canada
Correspondence to:
Correspondence to:
S Serra
Department of Pathology, University Health Network and Toronto Medical Laboratories, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, M5G 2C4, Canada;stefano.serra{at}uhn.on.ca
The introduction of endoscopy of the upper digestive tract as a routine diagnostic procedure has increased the number of duodenal biopsy specimens. Consequently, the pathologist is often asked to evaluate them. In this review, a practical approach to the evaluation of a duodenal biopsy specimen is discussed. An overview of the handling of specimens is given and the normal histology and commonly encountered diseases are discussed. Finally, a description of commonly seen infections is provided, together with an algorithmic approach for diagnosis.
Abbreviations: CMSE, cow’s milk protein-sensitive enteropathy; CMV, cytomegalovirus; DGM, duodenal gastric metaplasia; DPAS, diastase periodic acid Schiff; EMA, endomysial antibodies; EITCL, enteropathy-type intestinal T cell lymphoma; GFD, gluten-free diet; GSE, gluten-sensitive enteropathy; H&E, haematoxylin–eosin; IEL, intraepithelial lymphocyte; IPSID, immunoproliferative small intestinal disease; NSAID, non-steroidal anti-inflammatory drug; PAS, periodic acid Schiff; V:C ratio, villous to crypt ratio; TCR, T cell receptor; tTGA, transglutaminase antibody
Read all eLetters
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
eLetters:
- Full Text
- Full Text (PDF)
-
All Versions of this Article:
jcp.2005.031260v1
jcp.2005.031260v2
59/11/1133 most recent - Submit a response
- Read responses to this article
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
BMJ Learning
Topic Collections
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
