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This Article Full Text Full Text (PDF) All Versions of this Article: jcp.2005.031260v1 jcp.2005.031260v2 59/11/1133    most recent Submit a response Read responses to this article Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Serra, S Articles by Jani, P A Search for Related Content PubMed PubMed Citation Articles by Serra, S Articles by Jani, P A

An approach to duodenal biopsies

Department of Pathology, University Health Network and Toronto Medical Laboratories, Toronto, Ontario, Canada

Correspondence to:
S Serra
Department of Pathology, University Health Network and Toronto Medical Laboratories, 200 Elizabeth Street, 11th Floor, Toronto, Ontario, M5G 2C4, Canada;stefano.serra{at}uhn.on.ca
ABSTRACT
The introduction of endoscopy of the upper digestive tract as a routine diagnostic procedure has increased the number of duodenal biopsy specimens. Consequently, the pathologist is often asked to evaluate them. In this review, a practical approach to the evaluation of a duodenal biopsy specimen is discussed. An overview of the handling of specimens is given and the normal histology and commonly encountered diseases are discussed. Finally, a description of commonly seen infections is provided, together with an algorithmic approach for diagnosis.

Abbreviations: CMSE, cow’s milk protein-sensitive enteropathy; CMV, cytomegalovirus; DGM, duodenal gastric metaplasia; DPAS, diastase periodic acid Schiff; EMA, endomysial antibodies; EITCL, enteropathy-type intestinal T cell lymphoma; GFD, gluten-free diet; GSE, gluten-sensitive enteropathy; H&E, haematoxylin–eosin; IEL, intraepithelial lymphocyte; IPSID, immunoproliferative small intestinal disease; NSAID, non-steroidal anti-inflammatory drug; PAS, periodic acid Schiff; V:C ratio, villous to crypt ratio; TCR, T cell receptor; tTGA, transglutaminase antibody

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