REVIEW
Alveolar soft-part sarcoma: a review and update
1 Department of Laboratory Medicine and Pathology, Mayo Clinic Rochester, Minnesota, USA
2 Department of Pathology and Laboratory Medicine, Emory University Hospital, Atlanta, Georgia, USA
Correspondence to:
Correspondence to:
A L Folpe
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA; folpe.andrew{at}mayo.edu
Alveolar soft-part sarcoma (ASPS) is a rare, distinctive sarcoma, typically occurring in young patients. Although it displays a relatively indolent clinical course, the ultimate prognosis is poor and is often characterised by late metastases. Recently, our understanding of the genetic events underlying the pathogenesis of ASPS has greatly increased. The historical, histopathological, ultrastructural, immunohistochemical and genetic aspects of ASPS are reviewed in this article.
Abbreviations: ASPS, alveolar soft-part sarcoma; TFE3, transcription factor 3
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