CASE REPORT
e19a2 BCR–ABL fusion transcript in typical chronic myeloid leukaemia: a report of two cases
1 Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, Kolkata, India
2 Institute of Haematology and Transfusion Medicine, Kolkata
Correspondence to:
Correspondence to:
U B Dasgupta
Department of Biophysics, Molecular Biology and Genetics, University of Calcutta, 92 APC Road, Kolkata 700009, India; ubdgh{at}yahoo.co.in
This report describes two patients with chronic myeloid leukaemia (CML): one of them developed accelerated phase CML and died 8 years after diagnosis and the other is at the chronic phase. Sequence analysis of reverse transcription-polymerase chain reaction products showed the presence of BCR–ABL fusion transcript e19a2. This finding suggests that CML carrying µ-BCR breakpoint may exhibit a clinical course similar to typical CML.
Abbreviations: CML, chronic myeloid leukaemia
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