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ALK positive inflammatory myofibroblastic tumour of the pineal region

¹ Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK
² Department of Neuropathology, National Hospital for Neurology and Neurosurgery
³ Department of Neurosurgery, National Hospital for Neurology and Neurosurgery

Correspondence to:
Dr A J Clarke
Department of Neurology, National Hospital for Neurology and Neurosurgery, Queen Square, London WC1N 3BG, UK; alex{at}actualmedia.com
ABSTRACT
Inflammatory myofibroblastic tumours (IMTs) are an uncommon spindle cell neoplasm with a dense inflammatory infiltrate, usually encountered in children. IMTs of the central nervous system are extremely rare. This report describes the case of an IMT in a 61 year old man, in the pineal region. The tumour was completely excised, and immunohistochemistry demonstrated anaplastic lymphoma kinase 1 expression. There was no tumour recurrence during 18 months of follow up. Our case extends both the age range and sites of occurrence of this rare tumour.

Abbreviations: ALK, anaplastic lymphoma kinase; IMT, anaplastic lymphoma kinase

Keywords: inflammatory myofibroblastic tumour; inflammatory pseudotumour; anaplastic lymphoma kinase; anaplastic lymphoma kinase