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Journal of Clinical Pathology 2005;58:338-342
© 2005 BMJ Publishing Group Ltd & Association of Clinical Pathologists

REVIEW

BEST PRACTICE NO 183

BEST PRACTICE NO 183

Examination of parathyroid gland specimens

S J Johnson1, E A Sheffield2, A M McNicol3

1 Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK
2 Department of Pathology, Bristol Royal Infirmary, Bristol BS2 8HW, UK
3 Department of Pathology, Glasgow Royal Infirmary, Castle Street, Glasgow G4 0SF, UK

Correspondence to:
Dr S J Johnson
Department of Cellular Pathology, Royal Victoria Infirmary, Newcastle upon Tyne NE1 4LP, UK; Sarah.Johnson{at}nuth.northy.nhs.uk
ABSTRACT
The pathological examination of parathyroid glands is an essential component of the evaluation of hyperparathyroidism. Traditionally, this has involved intraoperative frozen sections during bilateral surgical exploration of the neck, to confirm removal of parathyroid tissue. With recent developments in imaging, some diseased glands can be localised preoperatively, enabling removal by minimally invasive, targetted surgery, with or without additional non-histological intraoperative procedures to confirm the removal of all hyperfunctioning parathyroid tissue. This article reviews these developments and describes the ideal approach to reporting parathyroid specimens.

Abbreviations: IOQPTH, intraoperative quick assay of intact parathyroid hormone; MEN, multiple endocrine neoplasia; MIP, minimally invasive parathyroidectomy

Keywords: parathyroidism; minimally invasive parathyroidectomy; parathyroid adenoma; parathyroid carcinoma; parathyroid hyperplasia






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