HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Best-Aguilera, C R Articles by Lomeli-Guerrero, A Search for Related Content PubMed PubMed Citation Articles by Best-Aguilera, C R Articles by Lomeli-Guerrero, A

Massive myeloid sarcoma affecting the central nervous system, mediastinum, retroperitoneum, liver, and rectum associated with acute myeloblastic leukaemia: a case report

¹ Departmento de Hematologia, Hospital General de Occidente, SSJ, Zapopan, Jalisco, 45170 México
² Centro Universitario de Ciencias de la Salud, Universidad de Guadalajara, 44290 Mexico

Correspondence to:
Dr C R Best-Aguilera
Av. Zoquipan, 1050 Zapopan Jal., México, 45175; bestvme{at}cencar.udg.mx
ABSTRACT
Myeloid sarcomas are extramedullary tumours with granulocytic precursors. When associated with acute myelogenous leukaemia (AML), these tumours usually affect no more than two different extramedullary regions. This report describes a myeloid sarcoma associated with AML with tumour formation at five anatomical sites. The patient was a 37 year old man admitted in September 1999 with a two month history of weight loss, symptoms of anaemia, rectal bleeding, and left facial nerve palsy. The anatomical sites affected were: the rectum, the right lobe of the liver, the mediastinum, the retroperitoneum, and the central nervous system. A bone marrow smear was compatible with AML M2. Flow cytometry showed that the peripheral blood was positive for CD4, CD11, CD13, CD14, CD33, CD45, and HLA-DR. A karyotypic study of the bone marrow revealed an 8;21 translocation. The presence of multiple solid tumours in AML is a rare event. Enhanced expression of cell adhesion molecules may be the reason why some patients develop myeloid sarcomas.

Abbreviations: AML, acute myelogenous leukaemia

Keywords: acute myelogenous leukaemia; myeloid sarcoma