HOME HELP FEEDBACK SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS REGISTER		Author Keyword(s) Vol Page [Advanced]

This Article Full Text Full Text (PDF) Submit a response Alert me when this article is cited Alert me when eLetters are posted Alert me if a correction is posted Citation Map Services Email this link to a friend Similar articles in this journal Similar articles in PubMed Add article to my folders Download to citation manager Request Permissions Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Suzuki, T Articles by Yoshimine, T Search for Related Content PubMed PubMed Citation Articles by Suzuki, T Articles by Yoshimine, T Pubmed/NCBI databases Medline Plus Health Information Brain Cancer

Clinicopathological study of cellular proliferation and invasion in gliomatosis cerebri: important role of neural cell adhesion molecule L1 in tumour invasion

¹ Department of Neurosurgery, Osaka University Medical School, 2–2, Yamadaoka, Suita, Osaka, 565–0871, Japan
² Department of Clinical Pathology, Mino City Hospital, 5-7-1 Kayano, Mino, Osaka, 562-0014, Japan

Correspondence to:
Dr S Izumoto
Department of Neurosurgery, Osaka University Medical School, 2–2, Yamadaoka, Suita, Osaka, 565–0871, Japan; sizumoto{at}nsurg.med.osaka-u.ac.jp Background/Aims: In patients with gliomatosis cerebri (GC), glial fibrillary acidic protein (GFAP) positive cells invade the entire brain, particularly the white matter. Because the nosological definition and histogenesis of GC remain controversial, the morphology and immunohistochemical staining patterns of neoplastic GC cells were compared with those of other gliomas.

Methods: An immunohistochemical analysis of neoplastic cells from four patients with GC and 20 with astrocytic tumours using antibodies against Ki-67, GFAP, and L1, the last of which is a neural cell adhesion molecule putatively related to glioma invasion.

Results: GC tumour cells can be divided into two types, those mainly composed of strongly GFAP and L1 positive gemistocytic cells, the other composed of small, GFAP and L1 negative spindle shaped cells. The two types did not differ with respect to Ki-67 positivity. Cells from patients with other gliomas were positive for GFAP but concurrent L1 expression was negative or weakly positive.

Conclusion: The strong expression of L1 in patients with GC and its poor expression in the 20 patients with other types of glioma, including those with GFAP positive gemistocytic astrocytomas, suggest that L1 expression may play a role in the histogenesis of GC.

Abbreviations: GC, gliomatosis cerebri; GFAP, glial fibrillary acidic protein; MRI, magnetic resonance imaging

This article has been cited by other articles:

				S. Bao, Q. Wu, Z. Li, S. Sathornsumetee, H. Wang, R. E. McLendon, A. B. Hjelmeland, and J. N. Rich Targeting Cancer Stem Cells through L1CAM Suppresses Glioma Growth Cancer Res., August 1, 2008; 68(15): 6043 - 6048. [Abstract] [Full Text] [PDF]

				M. Bredel, C. Bredel, D. Juric, G. R. Harsh, H. Vogel, L. D. Recht, and B. I. Sikic Functional Network Analysis Reveals Extended Gliomagenesis Pathway Maps and Three Novel MYC-Interacting Genes in Human Gliomas Cancer Res., October 1, 2005; 65(19): 8679 - 8689. [Abstract] [Full Text] [PDF]