SHORT REPORT
Postmortem diagnosis of chronic granulomatous disease: how worthwhile is it?
1 Department of Paediatric Immunology, Newcastle upon Tyne Hospitals NHS Trust, Newcastle upon Tyne NE4 6BE, UK
2 Department of Paediatrics, Sunderland Royal Hospital, Sunderland SR4 7TP, UK
3 Department of Paediatric Respiratory Medicine, Newcastle upon Tyne Hospitals NHS Trust, Freeman Hospital, Newcastle, NE7 7DN, UK
4 Department of Paediatric Intensive Care, Newcastle upon Tyne Hospitals NHS Trust
5 Department of Clinical Microbiology, Newcastle upon Tyne Hospitals NHS Trust
6 Department of Histopathology, Newcastle upon Tyne Hospitals NHS Trust, Royal Victoria Infirmary, Newcastle, NE1 4LP, UK
7 Immunology Laboratory, Newcastle upon Tyne Hospitals NHS Trust, Royal Victoria Hospital
8 Sanquin Research at CLB and Landsteiner Laboratory of the Academic Medical Centre, University of Amsterdam, 1066 CX Amsterdam, The Netherlands
Correspondence to:
Correspondence to:
Dr M Abinun
Children’s Bone Marrow Transplantation Unit, Newcastle General Hospital, Westgate Road, Newcastle upon Tyne, NE4 6BE, UK; Mario.Abinun{at}ncl.ac.uk
A previously healthy 11 year old boy died unexpectedly after a rapid course of progressive pneumonia. Postmortem microbiology and histopathology suggested an underlying diagnosis of chronic granulomatous disease. This was confirmed by neutrophil oxidative burst and gene mutation analysis of other family members, one of whom benefited from early bone marrow transplantation.
Abbreviations: CGD, chronic granulomatous disease
Keywords: chronic granulomatous disease; Burkholderia cepacia; palatal granulomatous mucositis; autoimmunity
CiteULike 
Complore 
Connotea 
Del.icio.us 
Digg 
Reddit 
Technorati What's this?
- Full Text
- Full Text (PDF)
- Submit a response
- Alert me when this article is cited
- Alert me when eLetters are posted
- Alert me if a correction is posted
- Citation Map
Services
- Email this link to a friend
- Similar articles in this journal
- Similar articles in PubMed
- Add article to my folders
- Download to citation manager
- Request Permissions
Citing Articles
Google Scholar
PubMed
Topic Collections
-
Molecular genetics
-
Immunology (including allergy)
-
Pneumonia (infectious disease)
-
TB and other respiratory infections
-
Histopathology
Bookmark with
Register for free content
The full back archive is now available for all BMJ Journals. Institutional subscribers may access the entire archive as part of their subscription. Personal subscribers will also have access to all content when logged in. Non-subscribers who register have free access to all articles published before 2006 right back to volume 1 issue 1. Register here to access the free archive of all BMJ Journals.
Don't forget to sign up for content alerts so you keep up to date with all the articles as they are published.
