CASE REPORT
A "crackleware" oesophagus
1 Department of Surgery, Academic Medical Centre/University of Amsterdam, Suite G4-123, Meibergdreef 9, 1105 AZ, The Netherlands
2 Department of Gastroenterology, Academic Medical Centre/University of Amsterdam
3 Department of Pathology, Academic Medical Centre/University of Amsterdam
Correspondence to:
Correspondence to:
Dr M Westerterp
Department of Surgery, Academic Medical Centre/University of Amsterdam, Suite G4-123, Meibergdreef 9, 1105 AZ Amsterdam, The Netherlands; m.westerterp{at}AMC.UVA.NL
This case report describes a 70 year old woman with excessive diffuse keratinisation of the oral cavity and oesophagus harbouring a squamous cell carcinoma. This excessive diffuse keratinisation of normally non-keratinised squamous epithelium could not be identified in normally non-keratinised epithelia in other parts of the body (the vagina), arguing against a genetic basis for this disorder. The term "crackleware" oesophagus was used to describe this entity, which has not been described previously in the English literature.
Abbreviations: CK, cytokeratin
Keywords: cytokeratins; hyperkeratosis; oesophagus; pancreatic metaplasia; squamous cell carcinoma
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