| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
|
|
|
|
|||||||||||||
|
|
|||||||||||||||
REVIEW |
Correspondence to:
Dr P A Marignani
Dalhousie University, Faculty of Medicine, Department of Biochemistry and Molecular Biology, Sir Charles Tupper Medical Building, Room 9S1, 5850 College Street, Halifax, Nova Scotia B3H-1X5, Canada; pmarigna{at}dal.ca
ABSTRACT
Mutations in the lkb1 gene are found in Peutz-Jeghers syndrome (PJS), with loss of heterozygosity or somatic mutations at the lkb1 locus, suggesting the gene product, the serine/threonine kinase LKB1, may function as a tumour suppressor. Patients with PJS are at a greater risk of developing cancers of epithelial tissue origin. It is widely accepted that the presence of hamartomatous polyps in PJS does not in itself lead to the development of malignancy. The signalling mechanisms that lead to these PJS related malignancies are not well understood. However, it is evident from the recent literature that LKB1 is a multitasking kinase, with unlimited potential in orchestrating cell activity. Thus far, LKB1 has been found to play a role in chromatin remodelling, cell cycle arrest, Wnt signalling, cell polarity, and energy metabolism, all of which may require the tumour suppressor function of this kinase and/or its catalytic activity.
Abbreviations: AMPK, 5'-AMP activated protein kinase; Brg1, Brahma related gene 1; Dvl, Dishevelled; JPS, juvenile polyposis syndrome; GSK-3ß, glygogen synthase kinase 3ß; LIP1, LKB1 interacting protein; par, partitioning-defective gene; PJS, Peutz-Jeghers syndrome; PKC, protein kinase C; smad4, SMA and MAD related protein 4; STRAD, STE20 related adaptor; VEGF, vascular endothelial growth factor; XEEK1, Xenopus laevis egg and embryonic kinase 1
Keywords: LKB1; serine threonine kinase; tumour suppressor
This article has been cited by other articles:
|
|
 |
|
  H. B. Pearson, A. McCarthy, C. M.P. Collins, A. Ashworth, and A. R. Clarke Lkb1 Deficiency Causes Prostate Neoplasia in the Mouse Cancer Res., April 1, 2008; 68(7): 2223 - 2232. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
K. D. Scott, S. Nath-Sain, M. D. Agnew, and P. A. Marignani LKB1 Catalytically Deficient Mutants Enhance Cyclin D1 Expression Cancer Res., June 15, 2007; 67(12): 5622 - 5627. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. Marshall Role of Insulin, Adipocyte Hormones, and Nutrient-Sensing Pathways in Regulating Fuel Metabolism and Energy Homeostasis: A Nutritional Perspective of Diabetes, Obesity, and Cancer Sci. Signal., August 1, 2006; 2006(346): re7 - re7. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. R. Laderoute, K. Amin, J. M. Calaoagan, M. Knapp, T. Le, J. Orduna, M. Foretz, and B. Viollet 5'-AMP-Activated Protein Kinase (AMPK) Is Induced by Low-Oxygen and Glucose Deprivation Conditions Found in Solid-Tumor Microenvironments. Mol. Cell. Biol., July 1, 2006; 26(14): 5336 - 5347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E Volikos, J Robinson, K Aittomaki, J-P Mecklin, H Jarvinen, A M Westerman, F W M de Rooji, T Vogel, G Moeslein, V Launonen, et al. LKB1 exonic and whole gene deletions are a common cause of Peutz-Jeghers syndrome. J. Med. Genet., May 1, 2006; 43(5): e18 - e18. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A Rody, U Holtrich, C Solbach, K Kourtis, G von Minckwitz, K Engels, S Kissler, R Gatje, T Karn, and M Kaufmann Methylation of estrogen receptor {beta} promoter correlates with loss of ER-{beta} expression in mammary carcinoma and is an early indication marker in premalignant lesions Endocr. Relat. Cancer, December 1, 2005; 12(4): 903 - 916. [Abstract] [Full Text] [PDF]
|
|
| HOME | HELP | FEEDBACK | SUBSCRIPTIONS | ARCHIVE | SEARCH | TABLE OF CONTENTS | REGISTER |
| Journal of Clinical Pathology | Molecular Pathology |
