CASE REPORT

Statin precipitated lactic acidosis?

R Neale¹, T M Reynolds² and W Saweirs¹

¹ Queen’s Hospital, Belvedere Road, Burton-on-Trent, Staffordshire, DE13 0RB, UK
² Queen’s Hospital, Burton-on-Trent and Division of Clinical Sciences, Wolverhampton University, Wolverhampton, UK

Correspondence to:
Correspondence to:
Professor T M Reynolds
Clinical Chemistry Department, Queen’s Hospital, Belvedere Road, Burton-on-Trent, Staffordshire, DE13 0RB, UK; tim.reynolds{at}burtonh-tr.wmids.nhs.uk

An 82 year old woman was admitted with worsening dyspnoea. Arterial blood gases were taken on air and revealed a pH of 7.39, with a partial pressure of CO₂ (pCO₂) of 1.2 kPa, pO₂ of 19.3 kPa, HCO₃ of 13.8 mmol/litre, and base excess of –16.3 mmol/litre: a compensated metabolic acidosis with hyperventilation induced hypocapnia, which is known to be a feature of lactic acidosis. There was also an increased anion gap ((Na140 + K4.0) – (Cl 106 + HCO₃ 13.8) = 24.2 mEq/litre (reference range, 7–16)), consistent with unmeasured cation. Lactate was measured and found to be raised at 3.33 mmol/litre (reference range, 0.9–1.7). After exclusion of common causes of lactic acidosis Atorvastatin was stopped and her acid–base balance returned to normal. Subsequently, thiamine was also shown to be deficient. The acidosis was thought to have been the result of a mitochondrial defect caused by a deficiency of two cofactors, namely: ubiquinone (as a result of inhibition by statin) and thiamine (as a result of dietary deficiency).

Abbreviations: ABGs, arterial blood gases; bd, twice daily; coQ₁₀, coenzyme Q₁₀; HMGCoA, hydroxymethylglutaryl CoA; od, once daily; qds, four times daily; P, partial pressure

Keywords: hydroxymethylglutaryl CoA reductase inhibitor; lactic acidosis; statin; thiamine deficiency; transketolase

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eLetters:

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Statin precipitated lactic acidosis: A very big question mark

Peter S Kruger, et al.

JCP Online, 2 Nov 2004 [Full text]

Response to Dr Kruger

Tim M Reynolds, et al.

JCP Online, 17 Jan 2005 [Full text]